Studies with Tritiated Polypeptide Hormones

Structural Studies on Polypeptide Hormones

The structures of three polypeptide hormones (glucagon, a 25-residue analogue of adrenocorticotropin, and parathyroid hormone) which contain enough residues to permit organization have been evaluated in aqueous solution by fluorescence and circular dichroism. The effects of pH, temperature, and guanidine on both tyrosyl and tryptophanyl emission have been measured. None of the fluorescence para...

Studies with Tritiated Mithramycin in C3H Mice1

The cytotoxic characteristics of the antibiotic mithramycin were studied by measuring the distribution of tritium-labeled mithramycin in C3H mice. The greatest concentrations of the isotope were in the kidneys and liver. The excretion of mithramycin-3H was rapid, and there was no evidence of metabolism of the carbohydrate moiety to carbon dioxide and water with loss through respiration. Althoug...

Chemical determination of polypeptide hormones.

The presence or absence of peptide hormones in tissue extracts may in certain cases be demonstrated by exposing the extracts to conditions under which characteristic fragments of the polypeptide molecule in question are formed and then analyzing for such fragments. An approximate quantitation of the hormones may also be achieved thereby. In the present work the COOH-terminal fragments of polype...

Polypeptide Hormones : molecular and cellular aspects

The cytochemical bioassay of polypeptide hormones.

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